Review
doi: 10.1016/j.tibs.2006.10.007.
Epub 2006 Nov 3.
Pathways for mRNA localization in the cytoplasm
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- PMID: 17084632
- DOI: 10.1016/j.tibs.2006.10.007
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Review
Pathways for mRNA localization in the cytoplasm
Trends Biochem Sci.
2006 Dec.
Abstract
Studies of the intracellular localization of mRNA have clearly demonstrated that certain subsets of mRNA are concentrated in discrete locations within the cytoplasm. Localization is one aspect of the post-transcriptional control of gene expression, and is intertwined with the translation and turnover of mRNA to achieve the goal of local protein production. Different mechanisms have been identified that enable localized mRNAs to target different subcellular compartments, and recent advances in understanding these pathways is reviewed here.
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