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Review
. 2006 Nov;4(5):333-4.
doi: 10.1016/j.cmet.2006.10.006.

EXtENDINg beta cell survival by UPRegulating ATF4 translation

Ronald C Wek  1 , Tracy G Anthony
Affiliations
Free article
Review

EXtENDINg beta cell survival by UPRegulating ATF4 translation

Ronald C Wek et al. Cell Metab. 2006 Nov.
Free article

Abstract

In this issue of Cell Metabolism, Daniel Drucker and colleagues (Yusta et al., 2006) explore how the incretin mimetic exendin-4 improves beta cell function and survival during ER stress. Their findings suggest that protein kinase A signaling elicited by GLP-1 receptor activation differentially modulates one arm of the unfolded protein response (UPR). Regulation of this UPR pathway leads to enhanced translational expression of ATF4, a transcription factor central for stress remedy and cell survival.

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