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Review
. 2006 Dec;27(4):705-24; abstract x.
doi: 10.1016/j.ccm.2006.07.001.

Genetic epidemiology of acute respiratory distress syndrome: implications for future prevention and treatment

Michelle Ng Gong  1
Affiliations
Review

Genetic epidemiology of acute respiratory distress syndrome: implications for future prevention and treatment

Michelle Ng Gong. Clin Chest Med. 2006 Dec.

Abstract

The genetic susceptibility to the development of and variable outcomes in acute lung injury/acute respiratory distress syndrome (ALI/ARDS) has become a topic of great interest in the pulmonary and critical care community. Published studies of variable genetic susceptibility to ALI/ARDS already have identified some important candidate genes and potential gene-environment interactions. This article reviews these recent studies, features of the current approach, and implications for future prevention and treatment in ALI. The challenges and potential contributions of genetic epidemiology to the future prevention and treatment in ALI are discussed.

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Figures

Fig. 1
Fig. 1
Criteria for strong candidate genes in ALI. The strongest candidates for investigation in ALI/ARDS are genes in which specific alleles have been linked with ALI/ARDS or related diseases such as sepsis, neonatal respiratory distress syndrome, or other critical illnesses. Alternately, in the absence of such data, there should be evidence supporting the importance of the gene product or function in ALI/ARDS. If a direct candidate-gene approach is used, additional evidence for the functional significance of the allele of interest should exist. (Adapted from Gong MN, Christiani DC. Genetic epidemiology of acute lung injury. In: Mathay MA, editor. Acute respiratory distress syndrome. New York: Marcel Dekker, Inc.; 2003. p. 392; with permission.)
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