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Review
. 2006 Nov;58(11):621-31.
doi: 10.1080/15216540600957438.

ERK1/2 MAP kinases in cell survival and apoptosis

Zhimin Lu  1 , Shuichan Xu
Affiliations
Free article
Review

ERK1/2 MAP kinases in cell survival and apoptosis

Zhimin Lu et al. IUBMB Life. 2006 Nov.
Free article

Abstract

ERK1/2 is an important subfamily of mitogen-activated protein kinases that control a broad range of cellular activities and physiological processes. ERK1/2 can be activated transiently or persistently by MEK1/2 and upstream MAP3Ks in conjunction with regulation and involvement of scaffolding proteins and phosphatases. Activation of ERK1/2 generally promotes cell survival; but under certain conditions, ERK1/2 can have pro-apoptotic functions.

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