[Mucoactive therapy and new aspects of the pathogenesis of chronic obstructive pulmonary disease]

Abstract

From the present-day view, the article considers the potential of mucoactive therapy, directed towards the correction of mucociliary clearance (MCC) as the leading protective mechanism of the respiratory organs. Despite the big number of therapeutic agents and methods affecting the mucous link of the mucociliary system, not many of them, according to direct non-invasive in vivo studies, have a significant effect on MCC; physiotherapeutic methods have certain advantages. This means that new approaches allowing effective correction of mucociliary insufficiency should be developed. The article demonstrates the prospects of application of some pharmacological and non-pharmacological agents and development of predictive methods based on study of molecular and cellular level of bronchopulmonary pathology pathogenesis. Chronic obstructive pulmonary disease model is used to demonstrate new aspects of the pathogenesis of chronic inflammatory process in the lungs.