Review
doi: 10.1016/j.neuron.2006.10.016.
Arc/Arg3.1: linking gene expression to synaptic plasticity and memory
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- PMID: 17088207
- DOI: 10.1016/j.neuron.2006.10.016
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Review
Arc/Arg3.1: linking gene expression to synaptic plasticity and memory
Neuron.
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Free article
Abstract
Arc/Arg3.1 is an effector immediate-early gene implicated in the consolidation of memories. Although cloned a decade ago, the physiological role of Arc/Arg3.1 in the brain has remained elusive. Four papers in this issue of Neuron address this function. These studies show that Arc/Arg3.1 regulates endophilin 3 and dynamin 2, two components of the endocytosis machinery. Genetic ablation of Arc/Arg3.1 in mice or overexpression in culture suggest that Arc/Arg3.1 regulates AMPA receptor trafficking and synaptic plasticity. Finally, Arc/Arg3.1 knockout mice show memory retention deficits. These recent developments provide new insights into the function of this popular activity-dependent neuronal marker.
Comment in
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Optimal information storage in noisy synapses under resource constraints.Neuron. 2006 Nov 9;52(3):409-23. doi: 10.1016/j.neuron.2006.10.017. Neuron. 2006. PMID: 17088208
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