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. 2007 Feb;51(2):759-62.
doi: 10.1128/AAC.00840-06. Epub 2006 Nov 6.

Synergistic interactions of the antiretroviral protease inhibitors saquinavir and ritonavir with chloroquine and mefloquine against Plasmodium falciparum in vitro

T S Skinner-Adams  1 , K T Andrews, L Melville, J McCarthy, D L Gardiner
Affiliations

Synergistic interactions of the antiretroviral protease inhibitors saquinavir and ritonavir with chloroquine and mefloquine against Plasmodium falciparum in vitro

T S Skinner-Adams et al. Antimicrob Agents Chemother. 2007 Feb.

Abstract

The antimalarial activity of several antiretroviral protease inhibitor combinations was investigated. Data demonstrate that ritonavir and saquinavir behave synergistically with chloroquine and mefloquine. These data, and interactions with pepstatin-A, E-64, and bestatin, suggest that human immunodeficiency virus protease inhibitors do not target digestive-vacuole plasmepsins.

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Figures

FIG. 1.
FIG. 1.
Isobolograms describing the interaction of saquinavir or ritonavir with chloroquine or mefloquine when tested against P. falciparum isolate Dd2. The test of each combination was repeated on two occasions in triplicate. All data points are shown. FIC, fractional inhibitory concentration.
FIG. 2.
FIG. 2.
Isobolograms describing the interaction of mefloquine and ritonavir when assessed against the P. falciparum isolates D10 and FAC8. The test of each combination was repeated on two occasions in triplicate. All data points are shown.
FIG. 3.
FIG. 3.
Isobolograms describing the interactions of saquinavir with the known hemoglobin digestion inhibitors pepstatin, E-64, and bestatin and of chloroquine in combination with pepstatin when assessed against P. falciparum. The test of each combination was repeated on two occasions in triplicate. All data points are shown.
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References

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