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. 1990 Nov;342(5):554-8.
doi: 10.1007/BF00169045.

Effects of Bay K 8644 on the spontaneous electrical and mechanical activities of the rat portal vein

K Shimamura  1 , S Sunano
Affiliations

Effects of Bay K 8644 on the spontaneous electrical and mechanical activities of the rat portal vein

K Shimamura et al. Naunyn Schmiedebergs Arch Pharmacol. 1990 Nov.

Abstract

Effects of Bay K 8644 on the spontaneous electrical and mechanical activities of the rat portal vein were studied. Bay K 8644 enhanced contractions in amplitude and duration. Bay K 8644 prolonged the duration of the spontaneous spike potential bursts and increased the number of spike potentials in a burst. These results indicate that the increase in the amplitude and duration of spontaneous contractions of the rat portal vein induced by Bay K 8644 are mediated mainly by the facilitation of the membrane electrical activity.

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