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Comparative Study
. 2006 Nov 20;95(10):1314-20.
doi: 10.1038/sj.bjc.6603457. Epub 2006 Oct 31.

Ovarian cancer in younger vs older women: a population-based analysis

J K Chan  1 , R Urban, M K Cheung, K Osann, J Y Shin, A Husain, N N Teng, D S Kapp, J S Berek, G S Leiserowitz
Affiliations
Comparative Study

Ovarian cancer in younger vs older women: a population-based analysis

J K Chan et al. Br J Cancer. .

Erratum in

  • Br J Cancer. 2007 Feb 12;96(3):534. Shin, J Y [added]
  • Br J Cancer. 2007 May 7;96(9):1492

Abstract

To compare the clinico-pathologic prognostic factors and survival of younger vs older women diagnosed with epithelial ovarian cancer. Demographic, clinico-pathologic, treatment, and surgery information were obtained from patients with ovarian cancer from the Surveillance, Epidemiology, and End Results Program from 1988 to 2001 and analysed using Kaplan-Meier estimates. Of 28 165 patients, 400 were <30 years (very young), 11 601 were 30-60 (young), and 16 164 were >60 (older) years of age. Of the very young, young, and older patients, 261 (65.3%), 4664 (40.2%), and 3643 (22.5%) had stage I-II disease, respectively (P<0.001). Across all stages, very young women had a significant survival advantage over the young and older groups with 5-year disease-specific survival estimates at 78.8% vs 58.8 and 35.3%, respectively (P<0.001). This survival difference between the age groups persists even after adjusting for race, stage, grade, and surgical treatment. Reproductive age (16-40 years) women with stage I-II epithelial ovarian cancer who received uterine-sparing procedures had similar survivals compared to those who underwent standard surgery (93.3% vs 91.5%, P=0.26). Younger women with epithelial ovarian cancer have a survival advantage compared to older patients.

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Figures

Figure 1
Figure 1
Kaplan–Meier disease-specific survival of patients based on age at diagnosis.
Figure 2
Figure 2
Kaplan–Meier disease-specific survival of reproductive age patients (age 16–40 years) with stage I–II (A) epithelial and (B) clear cell ovarian cancer.
See this image and copyright information in PMC

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