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. 2006 Dec 4;95(11):1593-7.
doi: 10.1038/sj.bjc.6603450. Epub 2006 Oct 31.

Human papillomavirus infection in Shenyang City, People's Republic of China: A population-based study

L K Li  1 , M Dai, G M Clifford, W Q Yao, A Arslan, N Li, J F Shi, P J F Snijders, C J L M Meijer, Y L Qiao, S Franceschi
Affiliations

Human papillomavirus infection in Shenyang City, People's Republic of China: A population-based study

L K Li et al. Br J Cancer. .

Abstract

To investigate the prevalence of, and risk factors for, cervical infection with human papillomavirus (HPV) in Shenyang City, People's Republic of China, we interviewed and obtained cervical cell samples from 685 women aged 15-59 years enumerated from local population lists. Human papillomavirus DNA was detected in cervical cell samples using a GP5+/6+-based PCR assay for 44 HPV types. Human papillomavirus prevalence was 16.8% overall and 13.6% among women without cervical abnormalities (16.6% and 12.4%, respectively, age-standardised to the world standard population), with no significant trends in HPV prevalence by age group. Of the 32 types identified, high-risk HPV types predominated in all age groups, HPV16 being the most common (3.4% of all women), followed by HPV52 (2.5%) and 58 (1.9%). Multiple-type infections accounted for 31.3% of all infected women. Not being married, reporting multiple sexual partners and husband's extramarital sexual relationships were all significantly associated with being HPV-positive. The disclosure of a relatively high HPV prevalence in Shenyang, in comparison with other worldwide populations, raises important questions concerning the prevention of cervical cancer in China, especially given the promising efficacy of prophylactic HPV vaccines.

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Figures

Figure 1
Figure 1
Age-specific prevalence of cervical HPV DNA and corresponding 95% CIs. Shenyang, China, 2005.
See this image and copyright information in PMC

References

    1. Anh PT, Hieu NT, Herrero R, Vaccarella S, Smith JS, Thuy NT, Nga NH, Duc NB, Ashley R, Snijders POF, Meijer CJLM, Muñoz N, Parkin DM, Franceschi S (2003) Human papillomavirus infection among women in South and North Vietnam. Int J Cancer 104: 213–220 - PubMed
    1. Chen XS, Gong XD, Liang GJ, Zhang GC (2000) Epidemiologic trends of sexually transmitted diseases in China. Sex Transm Dis 27: 138–142 - PubMed
    1. Clifford GM, Franceschi S (2005) HPV in sub-Saharan Africa [editorial]. Papillomavirus Rep 16: 322–326
    1. Clifford GM, Gallus S, Herrero R, Muñoz N, Snijders PJF, Vaccarella S, Anh PTH, Ferreccio C, Hieu NT, Matos E, Molano M, Rajkumar R, Ronco G, de Sanjosé S, Shin HR, Sukvirach S, Thomas JO, Tunsakul S, Meijer CJLM, Franceschi S (2005) Worldwide distribution of human papillomavirus types in cytologically normal women in the International Agency for Research on Cancer HPV prevalence surveys: a pooled analysis. Lancet 366: 991–998 - PubMed
    1. Clifford GM, Smith JS, Plummer M, Muñoz N, Franceschi S (2003) Human papillomavirus types in invasive cervical cancer worldwide: a meta-analysis. Br J Cancer 88: 63–73 - PMC - PubMed

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