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. 2006 Dec 4;95(11):1525-8.
doi: 10.1038/sj.bjc.6603441. Epub 2006 Oct 31.

Molecular determination of epidermal growth factor receptor in normal and neoplastic colorectal mucosa

G Piazzi  1 , P Paterini, C Ceccarelli, M A Pantaleo, G Biasco
Affiliations

Molecular determination of epidermal growth factor receptor in normal and neoplastic colorectal mucosa

G Piazzi et al. Br J Cancer. .

Abstract

The epidermal growth factor receptor (EGFr) is considered a major target for treatment of colorectal cancer (CRC). We found a mean EGFr content significantly lower but more activated in colonic neoplastic tissue than in paired normal mucosa. Phosphorylated (pY1068) EGFr detection in CRC may be a better tool than EGFr detection to select patients for targeted therapies.

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Figures

Figure 1
Figure 1
EGFr content in normal mucosa and in neoplastic tissue. Paired protein (A) and mRNA (B) samples are connected by lines. Box-plot graphic analyses are also shown. Scatterplot graphic analysis for EGFr protein (C) and mRNA (D) content are reported. Each dot represents EGFr protein or mRNA content in normal mucosa and neoplastic tissue of the same patient.
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References

    1. Chung KI, Shia J, Kemeny NE, Shah M, Schwartz GK, Tse A, Hamilton E, Pan D, Schrag D, Schwartz L, Klimstra DS, Fridman D, Kelsen DP, Saltz LB (2005) Cetuximab shows activity in colorectal cancer patients with tumors that do not express the epidermal growth factor receptor by immunohistochemistry. J Clin Oncol 23: 1803–1810 - PubMed
    1. Cunningham D, Humblet Y, Siena S, Khayat D, Bleiberg H, Santoro A, Bets D, Mueser M, Harstrick A, Verslype C, Chau I, Van Cutsem E (2004) Cetuximab monotherapy and cetuximab plus irinotecan in irinotecan-refractory metastatic colorectal cancer. N Engl J Med 351: 337–345 - PubMed
    1. Dei Tos AP, Ellis I (2005) Assessing epidermal growth factor receptor expression in tumours: what is the value of current test methods? Eur J Cancer 41: 1383–1392 - PubMed
    1. Goldstein NS, Armin M (2001) Epidermal growth factor receptor immunohistochemical reactivity in patients with American Joint Committee on Cancer Stage IV colon adenocarcinoma: implications for a standardized scoring system. Cancer 92: 1331–1346 - PubMed
    1. Keese M, Magdeburg RJ, Herzog T, Hasenberg T, Offterdinger M, Pepperkok R, Sturm JW, Bastiaens PI (2005) Imaging epidermal growth factor receptor phosphorylation in human colorectal cancer cells and human tissues. J Biol Chem 280: 27826–27831 - PubMed

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