Biopolymer-based biomaterials as scaffolds for tissue engineering

Abstract

Biopolymers as biomaterials and matrices in tissue engineering offer important options in control of structure, morphology and chemistry as reasonable substitutes or mimics of extracellular matrix systems. These features also provide for control of material functions such as mechanical properties in gel, fiber and porous scaffold formats. The inherent biodegradability of biopolymers is important to help regulate the rate and extent of cell and tissue remodeling in vitro or in vivo. The ability to genetically redesign these polymer systems to bioengineer appropriate features to regulate cell responses and interactions is another important feature that offers both fundamental insight into chemistry-structure-function relationships as well as direct utility as biomaterials. Biopolymer matrices for biomaterials and tissue engineering can directly influence the functional attributes of tissues formed on these materials and suggest they will continue play an increasingly important role in the field.