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Comparative Study
. 2006 Nov;6(11):2427-30.
doi: 10.1021/nl061412u.

Multifunctional polymeric micelles as cancer-targeted, MRI-ultrasensitive drug delivery systems

Norased Nasongkla  1 , Erik Bey, Jimin Ren, Hua Ai, Chalermchai Khemtong, Jagadeesh Setti Guthi, Shook-Fong Chin, A Dean Sherry, David A Boothman, Jinming Gao
Affiliations
Comparative Study

Multifunctional polymeric micelles as cancer-targeted, MRI-ultrasensitive drug delivery systems

Norased Nasongkla et al. Nano Lett. 2006 Nov.

Abstract

We describe the development of multifunctional polymeric micelles with cancer-targeting capability via alpha(v)beta(3) integrins, controlled drug delivery, and efficient magnetic resonance imaging (MRI) contrast characteristics. Doxorubicin and a cluster of superparamagnetic iron oxide (SPIO) nanoparticles were loaded successfully inside the micelle core. The presence of cRGD on the micelle surface resulted in the cancer-targeted delivery to alpha(v)beta(3)-expressing tumor cells. In vitro MRI and cytotoxicity studies demonstrated the ultrasensitive MRI imaging and alpha(v)beta(3)-specific cytotoxic response of these multifunctional polymeric micelles.

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