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Review
. 1991;98(1):63-72.

Comparative studies on myelin proteins in mammalian peripheral nerve

Affiliations
  • PMID: 1709080
Review

Comparative studies on myelin proteins in mammalian peripheral nerve

K Uyemura et al. Comp Biochem Physiol C Comp Pharmacol Toxicol. 1991.

Abstract

Myelin proteins in mammalian peripheral nerve were studied comparatively. 1. While each content of P1 and P2 in the myelin varied among species, additional content of P1 and P2 are relatively constant. 2. The antigenic determinants of P2 for induction of experimental allergic neuritis were reported. 3. Amino acid sequence analysis of P0 revealed that P0 is conserved across species and belongs to the immunoglobulin superfamily. 4. The characteristic carbohydrate chain of P0 containing sulfate and sialic acid showed a positive reaction to the molecule-related immunity and adhesion. 5. Molecular architecture of the myelin is discussed.

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