Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2006 Dec;6(12):961-7.
doi: 10.1038/nrc2011. Epub 2006 Nov 9.

The blood peptidome: a higher dimension of information content for cancer biomarker discovery

Emanuel F Petricoin  1 , Claudio Belluco, Robyn P Araujo, Lance A Liotta
Affiliations
Review

The blood peptidome: a higher dimension of information content for cancer biomarker discovery

Emanuel F Petricoin et al. Nat Rev Cancer. 2006 Dec.

Abstract

The low-molecular-weight range of the circulatory proteome is termed the 'peptidome', and could be a rich source of cancer-specific diagnostic information because it is a 'recording' of the cellular and extracellular enzymatic events that take place at the level of the cancer-tissue microenvironment. This new information archive seems to mainly exist in vivo, bound to high-abundance proteins such as albumin. Measuring panels of peptidome markers might be more sensitive and specific than conventional biomarker approaches. We discuss the advantages and disadvantages of various methods for studying the peptidome.

PubMed Disclaimer

References

    1. Nature. 2003 Oct 30;425(6961):905 - PubMed
    1. Trends Biotechnol. 2003 Jul;21(7):301-5 - PubMed
    1. Clin Chem. 2002 Aug;48(8):1296-304 - PubMed
    1. Endocrinology. 2004 Feb;145(2):627-38 - PubMed
    1. Clin Chem. 2003 Aug;49(8):1272-5 - PubMed

Publication types

MeSH terms

LinkOut - more resources