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Case Reports
. 2007 Apr;82(4):321-4.
doi: 10.1002/ajh.20806.

Osseous metaplasia in diffuse large B-cell lymphoma of the kidney

Paul N Meyer  1 , Hytham Al-Masri, Serhan Alkan
Affiliations
Free article
Case Reports

Osseous metaplasia in diffuse large B-cell lymphoma of the kidney

Paul N Meyer et al. Am J Hematol. 2007 Apr.
Free article

Abstract

A 57-year-old female with a history of diffuse large B-cell lymphoma (DLBCL) presented with a renal mass. Microscopic analysis of the nephrectomy specimen revealed DLBCL, confirmed by immunohistochemical analysis (CD45, CD20, CD3, pan-keratin) and polymerase chain reaction (PCR). Multiple spicules of metaplastic bone were identified within the tumor mass, but not within the uninvolved kidney parenchyma. No evidence of bone or dystrophic calcification was detected on the pre-nephrectomy computerized tomography (CT) scan. To our knowledge, this is the first incidence of osseous metaplasia occurring within DLBCL. The pathogenesis of osseous metaplasia is briefly discussed.

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