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. 1991 Jun;65(6):3359-64.
doi: 10.1128/JVI.65.6.3359-3364.1991.

Feline immunodeficiency virus infects both CD4+ and CD8+ T lymphocytes

W C Brown  1 , L Bissey, K S Logan, N C Pedersen, J H Elder, E W Collisson
Affiliations

Feline immunodeficiency virus infects both CD4+ and CD8+ T lymphocytes

W C Brown et al. J Virol. 1991 Jun.

Abstract

Monoclonal populations of feline T cells, derived from a specific-pathogen-free cat and expressing either the CD4 or CD8 surface antigen, were infected in vitro with two geographically distinct isolates of feline immunodeficiency virus (FIV). Both infected T-cell subsets exhibited decreased cell viability, expressed FIV-encoded proteins, and generated reverse transcriptase activity. All clones examined retained their original surface phenotype after infection. It appears, therefore, that both CD4+ and CD8+ T cells may be productively infected by FIV in vivo.

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