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. 1991 Jun;65(6):3359-64.
doi: 10.1128/JVI.65.6.3359-3364.1991.

Feline immunodeficiency virus infects both CD4+ and CD8+ T lymphocytes

W C Brown  1 , L Bissey, K S Logan, N C Pedersen, J H Elder, E W Collisson
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Feline immunodeficiency virus infects both CD4+ and CD8+ T lymphocytes

W C Brown et al. J Virol. 1991 Jun.

Abstract

Monoclonal populations of feline T cells, derived from a specific-pathogen-free cat and expressing either the CD4 or CD8 surface antigen, were infected in vitro with two geographically distinct isolates of feline immunodeficiency virus (FIV). Both infected T-cell subsets exhibited decreased cell viability, expressed FIV-encoded proteins, and generated reverse transcriptase activity. All clones examined retained their original surface phenotype after infection. It appears, therefore, that both CD4+ and CD8+ T cells may be productively infected by FIV in vivo.

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References

    1. J Acquir Immune Defic Syndr. 1991;4(3):219-27 - PubMed
    1. Biochem Biophys Res Commun. 1984 May 31;121(1):126-33 - PubMed
    1. Cell. 1986 Nov 7;47(3):333-48 - PubMed
    1. Vet Rec. 1988 Jan 23;122(4):84-6 - PubMed
    1. Science. 1986 Jan 24;231(4736):382-5 - PubMed

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