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. 2007 Jan;35(Database issue):D51-4.
doi: 10.1093/nar/gkl797. Epub 2006 Nov 11.

PolymiRTS Database: linking polymorphisms in microRNA target sites with complex traits

Lei Bao  1 , Mi Zhou, Ligang Wu, Lu Lu, Dan Goldowitz, Robert W Williams, Yan Cui
Affiliations

PolymiRTS Database: linking polymorphisms in microRNA target sites with complex traits

Lei Bao et al. Nucleic Acids Res. 2007 Jan.

Abstract

Polymorphism in microRNA Target Site (PolymiRTS) database is a collection of naturally occurring DNA variations in putative microRNA target sites. PolymiRTSs may affect gene expression and cause variations in complex phenotypes. The database integrates sequence polymorphism, phenotype and expression microarray data, and characterizes PolymiRTSs as potential candidates responsible for the quantitative trait locus (QTL) effects. It is a resource for studying PolymiRTSs and their implications in phenotypic variations. PolymiRTS database can be accessed at http://compbio.utmem.edu/miRSNP/.

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Figures

Figure 1
Figure 1
Conceptual QTL model. A PolymiRTS (triangle) may cause the gene expression variation (diamond) in segregating population and a cis-acting eQTL is observed. The variation in gene expression in turn may cause phenotype variation (rectangle) and a pQTL is observed.
Figure 2
Figure 2
Methods of identifying and annotating PolymiRTS.
See this image and copyright information in PMC

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