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Case Reports
. 2007 Jan;39(1):49-52.
doi: 10.1038/sj.bmt.1705540. Epub 2006 Nov 13.

Central nervous system graft-versus-host disease: report of two cases and literature review

R T Kamble  1 , C-C Chang, S Sanchez, G Carrum
Affiliations
Case Reports

Central nervous system graft-versus-host disease: report of two cases and literature review

R T Kamble et al. Bone Marrow Transplant. 2007 Jan.

Abstract

Two patients with a plausible diagnosis of central nervous system graft-versus-host disease (CNS-GVHD) are described. Both presented with neurological manifestations 6 and 18 months following allogeneic transplant with hemiparesis, seizure, encephalopathy and magnetic resonance findings of hyperintense white matter lesions on T-2 weighed images. Brain biopsy in one and autopsy in the other revealed profound perivascular lymphocytic infiltrates composed predominantly of T-lymphocytes that were of donor origin. Although an unequivocal diagnosis of CNS-GVHD is difficult to establish, the transplantation community should be aware of this controversial entity.

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