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. 2007 Sep 14;121(1):115-6.
doi: 10.1016/j.ijcard.2006.08.049. Epub 2006 Nov 13.

Prevalence and spectrum of mutations in the sarcomeric troponin T and I genes in a cohort of Spanish cardiac hypertrophy patients

Mónica García-Castro, Julián R Reguero, César Morís, Cristina Alonso-Montes, José R Berrazueta, Rocío Sainz, Victoria Alvarez, Eliecer Coto

Prevalence and spectrum of mutations in the sarcomeric troponin T and I genes in a cohort of Spanish cardiac hypertrophy patients

Mónica García-Castro et al. Int J Cardiol. .

Abstract

We sequenced the coding exons of the cardiac troponins T (TNNT2) and I (TNNI3) genes in 115 Spanish HCM-patients (32% with a family history of the disease). Only two (2%) had mutations in the TNNT2 (Arg278>Cys and Arg92>Lys). These mutations were associated with variable clinical outcomes. No patient had TNNI3-mutation. We also genotyped these patients and 320 healthy controls for a 5 bp insertion/deletion (I/D) polymorphism in intron 3 of TNNT2. DD-homozygotes for the 5 bp I/D polymorphism were significantly more frequent among the patients (OR=1.83, 95% CI=2.10-5.16).

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