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. 2006 Dec;40(4):360-4.
doi: 10.1016/j.ymeth.2006.09.001.

Functional genomics of histone modification and non-histone chromosomal proteins using the polytene chromosomes of Drosophila

Joel C Eissenberg  1
Affiliations

Functional genomics of histone modification and non-histone chromosomal proteins using the polytene chromosomes of Drosophila

Joel C Eissenberg. Methods. 2006 Dec.

Abstract

Knowing the genomic distribution of chromosomal proteins and of histone modifications provides essential insight into function. The giant polytene chromosomes of the Drosophila larval salivary glands provide a high-resolution genomic map with a resolution exceeded only by chromatin immunoprecipitation. Immunofluorescence localization of chromosomal proteins and specific post-translational modifications of histones is a simple and rapid tool for the functional genomics of chromosomal proteins.

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