Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2006 Nov 14;103(46):17071-2.
doi: 10.1073/pnas.0608653103. Epub 2006 Nov 13.

Germ cells carry the epigenetic benefits of grandmother's diet

Craig A Cooney  1
Affiliations
Comment

Germ cells carry the epigenetic benefits of grandmother's diet

Craig A Cooney. Proc Natl Acad Sci U S A. .
No abstract available

PubMed Disclaimer

Conflict of interest statement

Conflict of interest statement: The author acknowledges U.S. patent no. 6,541,680 and U.S. patent application 10402704. However, these have no influence on the content of this commentary.

Figures

Fig. 1.
Fig. 1.
Experimental transgenerational breeding design of Cropley et al. (5). Female mice (a/a, black) are mated with male mice (Avy/a, pseudoagouti or mottled) in the P1 generation. Female mice are fed either a control or a methyl-supplemented diet during midgestation in the P1 generation. All other mice receive control diet. Pseudoagouti dams (Avy/a) of the F1 generation are mated with a/a, black sires to produce the F2 generation. Both the F1 and F2 generation mice from methyl-supplemented P1 dams show a greater degree of agouti coat color than F1 and F2 generation mice from control diet P1 dams. The distribution of phenotypes shown is only to illustrate the trend. See Cropley et al. (5) for phenotype percentages in each population.
See this image and copyright information in PMC

Comment on

References

    1. Wolff GL, Kodell RL, Moore SR, Cooney CA. FASEB J. 1998;12:949–957. - PubMed
    1. Gaudet F, Rideout WM III, Meissner A, Dausman J, Leonhardt H, Jaenisch R. Mol Cell Biol. 2004;24:1640–1648. - PMC - PubMed
    1. Wolff GL. Genetics. 1978;88:529–539. - PMC - PubMed
    1. Morgan HD, Sutherland HG, Martin DI, Whitelaw E. Nat Genet. 1999;23:314–318. - PubMed
    1. Cropley JE, Suter CM, Beckman KB, Martin DIK. Proc Natl Acad Sci USA. 2006;103:17308–17312. - PMC - PubMed

LinkOut - more resources