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. 2006 Nov;22(13):1127-31.
doi: 10.1016/s0828-282x(06)70949-7.

The carotid-femoral (aortic) pulse wave velocity as a marker of arterial stiffness in familial Mediterranean fever

Mustafa Yildiz  1 , Seval Masatlioglu, Pinar Seymen, Erman Aytac, Banu Sahin, H Oktay Seymen
Affiliations

The carotid-femoral (aortic) pulse wave velocity as a marker of arterial stiffness in familial Mediterranean fever

Mustafa Yildiz et al. Can J Cardiol. 2006 Nov.

Abstract
in English, French

Aim: The purpose of the present study was to test the hypothesis that chronic inflammation impairs vascular function and leads to an arterial pulse wave velocity (PWV) increase in patients with familial Mediterranean fever (FMF).

Patients and methods: Twenty-three patients (17 women) with FMF, and 23 age- and sex-matched controls were recruited. Aortic PWV was determined by using an automatic device (Complior Colson, Createch Industrie, France) that allowed on-line pulse wave recording and automatic calculation of the PWV.

Results: The PWV was slightly higher in patients with FMF than in control subjects (P=0.05). A significant correlation between PWV and age (P<0.001, r=0.67), body mass index (P<0.001, r=0.52) and leukocytes (P<0.001, r=0.66) was found in both groups combined and also in patients with FMF (P<0.001, r=0.73; P=0.01, r=0.52; P<0.001, r=0.69, respectively).

Conclusion: The PWV was slightly higher in patients with FMF compared with control subjects. Colchicine, an anti-inflammatory drug treatment, may have reduced the expected increased level of PWV in FMF patients. PWV is influenced by age, body mass index and leukocytes.

OBJECTIF: Le but de la présente étude était de vérifier l’hypothèse selon laquelle l’inflammation chronique peut nuire à la fonction vasculaire et entraîner une accélération de la vélocité de l’onde de pouls artérielle chez des patients atteints de fièvre méditerranéenne familiale (FMF).

PATIENTS ET MÉTHODES: Vingt-trois patients (17 femmes) atteints de FMF et 23 témoins assortis selon l’âge et le sexe, ont été recrutés. La vélocité de l’onde de pouls aortique a été déterminée à l’aide d’un instrument automatique (Complior Colson, Createch Industrie, France) qui a permis l’enregistrement de l’onde de pouls en ligne et le calcul automatique de sa vélocité.

RÉSULTATS: La vélocité de l’onde de pouls s’est révélée légèrement plus rapide chez les patients atteints de FMF que chez les témoins (p = 0,05). Des corrélations significatives entre la vélocité de l’onde de pouls et l’âge (p < 0,001, r = 0,67), l’indice de masse corporelle (p < 0,001, r = 0,52) et les leucocytes (p < 0,001, r = 0,66) ont été observées dans les deux groupes combinés et également chez les patients atteints de FMF (p < 0,001, r = 0,73; p = 0,01, r = 0,52; p < 0,001, r = 0,69, respectivement).

CONCLUSION: La vélocité de l’onde de pouls s’est révélée légèrement plus rapide chez les patients atteints de FMF comparativement aux témoins. La colchicine, un anti-inflammatoire, peut avoir réduit le taux d’augmentation prévu de la vélocité de l’onde de pouls chez les patients. Ce paramètre subit l’influence de l’âge, de l’indice de masse corporelle et des leucocytes.

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Figures

Figure 1
Figure 1
Pulse wave velocity (9.22 m/s [mean 9.42±0.19 m/s]) and pulse wave propagation time (67 s) in the 10th patient. dB Decibel
Figure 2
Figure 2
The carotid-femoral pulse wave velocity (PWV) is slightly increased in patients with familial Mediterranean fever (FMF) compared with the control (CONT) group (P=0.05). DBP Diastolic blood pressure; SBP Systolic blood pressure
See this image and copyright information in PMC

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