doi: 10.1254/jjp.55.157.
Clonidine reduces substance P binding in rat spinal cord membrane preparation
Affiliations
- PMID: 1710300
- DOI: 10.1254/jjp.55.157
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Clonidine reduces substance P binding in rat spinal cord membrane preparation
Jpn J Pharmacol.
1991 Jan.
Free article
Abstract
The effects of clonidine on substance P (SP) binding was investigated using rat brain and spinal cord membrane preparations preincubated with various concentrations of clonidine. [3H]SP specific binding in the spinal cord was significantly decreased with 10(-4) M clonidine, but no effect on binding was seen in the brain. Scatchard analysis of SP binding indicated that Bmax was significantly depressed without changing the affinity. The mechanism of clonidine-induced analgesia includes a spinal neural component and action on the SP receptors.
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