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Case Reports
. 2007 Dec;16 Suppl 3(Suppl 3):255-9.
doi: 10.1007/s00586-006-0252-3. Epub 2006 Nov 14.

Cervical intramedullary granuloma of Brucella: a case report and review of the literature

Kemal Nas  1 , Nebahat Tasdemir, Erkan Cakmak, Mustafa Serdar Kemaloglu, Yasar Bukte, Mehmet Faruk Geyik
Affiliations
Case Reports

Cervical intramedullary granuloma of Brucella: a case report and review of the literature

Kemal Nas et al. Eur Spine J. 2007 Dec.

Erratum in

  • Eur Spine J. 2007 Dec;16 Suppl 3:260

Abstract

The aim of this study was to present a unique case of intramedullary brucellar granuloma (IBG) and to discuss the diagnosis and management. To our knowledge, only one case of thoracic IBG has been reported previously, and our case is the first in cervical spine. A 35-year-old female patient was admitted with headache, pain and weakness in her four extremities. She had no gastrointestinal symptoms and fever. She had been diagnosed with Brucella meningitis 3 months ago and a triple therapy of doxycyclin, rifampicin and trimetoprim/sulfametoxazol (TMP/SMZ) had been started. Medical history revealed that she had ingested raw cheese and taken her medication improperly. Loss of strength was detected in her four extremities, which led us to assume the formation of a mass lesion at cervical level. Therefore, we performed a magnetic resonance imaging scan and found enhancement of an intramedullary mass lesion at cervical 1-2 level. Diagnosis of neurobrucellosis was confirmed by titer of >1/160 Brucella antibodies both in blood and cerebrospinal fluid. Based on these findings, brucellar granuloma of cervical spine was diagnosed and a combination therapy of doxycyclin, TMP/SMZ and rifampicin was administered for additional 6 months. At the ninth month of treatment, the patient recovered both radiologically and clinically. Our case is unique, in terms of cervical IBG formation. The excellent response to antimicrobial therapy in our patient suggests that, a trial of medical treatment for 6 months may be effective in such cases.

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Figures

Fig. 1
Fig. 1
a, b Contrast-enhanced T1-weighted sagittal and axial scans demonstrate intramedullary lesion with smooth margin, and homogeneous enhancement at the C2 level of the cervical spinal cord. At the axial scan, the lesion located on the right side of the cord and extending to the epidural space
Fig. 2
Fig. 2
Post medication images after 2 years. a, b Contrast-enhanced T1-weighted sagittal and axial scans; contrast enhancement and thickening are not present. c T2-weighted sagittal scan; the lesion and thickening are not seen
See this image and copyright information in PMC

References

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