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. 2007 Mar;34(1):53-60.
doi: 10.1007/s11033-006-9015-9. Epub 2006 Nov 14.

Role of cysteine 341 and arginine 348 of GLP-1 receptor in G-protein coupling

Aljosa Bavec  1 , Yang Jiang, Ulo Langel, Matjaz Zorko
Affiliations

Role of cysteine 341 and arginine 348 of GLP-1 receptor in G-protein coupling

Aljosa Bavec et al. Mol Biol Rep. 2007 Mar.

Abstract

We have demonstrated the ability of peptides derived from the third intracellular loop of GLP-1 receptor to differently modulate activity of four different types of G-proteins overexpressed in sf9 cells. In this respect, the involvement of Cys(341) in inhibition of G(s) and Cys(341) in activation of G(s) and in inhibition of G(i1,) G(o), and G(11), respectively, indicates their potential role in discrimination between different types of G-proteins. Moreover, these two amino acids from the third intracellular loop might represent an important novel targets for covalent modification by downstream regulators in signaling through GLP-1 receptor.

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