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. 2006 Nov 22;128(46):14796-7.
doi: 10.1021/ja064479s.

Oxidative amide synthesis and N-terminal alpha-amino group ligation of peptides in aqueous medium

Wing-Kei Chan  1 , Chi-Ming Ho, Man-Kin Wong, Chi-Ming Che
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Oxidative amide synthesis and N-terminal alpha-amino group ligation of peptides in aqueous medium

Wing-Kei Chan et al. J Am Chem Soc. .

Abstract

A new method for oxidative synthesis of amides from alkynes and amines in high yields (up to 96%) using [Mn(2,6-Cl2TPP)Cl] 1 as a catalyst and Oxone/H2O2 as an oxidant in aqueous medium has been developed. This method could be used for N-terminal alpha-amino group ligation of unprotected peptides with aryl, aliphatic, and internal alkynes under mild conditions.

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