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. 2006 Dec;16(6):235-6.
doi: 10.1097/01.ypg.0000242193.28526.b3.

Lack of association of an insertion/deletion polymorphism in the G protein-coupled receptor 50 with bipolar disorder in a Northern Swedish population

Maaike Alaerts, Tine Venken, An-Sofie Lenaerts, Sonia De Zutter, Karl-Fredrik Norrback, Rolf Adolfsson, Jurgen Del-Favero

Lack of association of an insertion/deletion polymorphism in the G protein-coupled receptor 50 with bipolar disorder in a Northern Swedish population

Maaike Alaerts et al. Psychiatr Genet. 2006 Dec.

Abstract

GPR50 is a G protein-coupled receptor, located on Xq28 and related to the melatonin receptor family. It is suggested as a functional and positional candidate gene for bipolar disorder (BP). Recently an insertion/deletion polymorphism in GPR50, Delta502-505, was found to be associated with BP in a Scottish association sample (P=0.007). When the analysis was restricted to female subjects, the association increased in significance (P=0.00023). We attempted to replicate this finding in a Northern Swedish association sample, but no significant association was detected (P=0.7, women only: P=0.65).

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