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Comparative Study
. 2006 Dec 15;194(12):1697-701.
doi: 10.1086/509509. Epub 2006 Nov 2.

Blinded case-control study of the relationship between human coronavirus NL63 and Kawasaki syndrome

Samuel R Dominguez  1 , Marsha S Anderson, Mary P Glodé, Christine C Robinson, Kathryn V Holmes
Affiliations
Comparative Study

Blinded case-control study of the relationship between human coronavirus NL63 and Kawasaki syndrome

Samuel R Dominguez et al. J Infect Dis. .

Abstract

We conducted a blinded, case-control, retrospective study in pediatric patients hospitalized at The Children's Hospital, Denver, Colorado, to determine whether human coronavirus (HCoV)-NL63 infection is associated with Kawasaki syndrome (KS). Over the course of a 7-month period, nasopharyngeal-wash samples from 2 (7.7%) of 26 consecutive children with KS and 4 (7.7%) of 52 matched control subjects tested positive for HCoV-NL63 by reverse transcription-polymerase chain reaction. These data suggest that, although HCoV-NL63 was circulating in children in our community during the time of the study, the prevalence of infection with HCoV-NL63 was not greater in patients with KS than in control subjects.

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References

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