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Comment
. 2006 Nov 17;127(4):675-7.
doi: 10.1016/j.cell.2006.11.003.

A new function for p53 ubiquitination

Yuko Hirano  1 , Ze'ev Ronai
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A new function for p53 ubiquitination

Yuko Hirano et al. Cell. .
Free article

Abstract

The amount of p53 protein in a cell is normally limited by ubiquitin-dependent degradation. In this issue of Cell, Le Cam et al. (2006) reveal that p53 ubiquitination contributes to transcriptional activation rather than protein stability. These results may provide insight into how p53 can modulate diverse cellular processes such as growth arrest and apoptosis.

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