Thymus transplantation. Reconstitution of cellular immunity in a four-year-old patient with T-cell deficiency
- PMID: 171111
- PMCID: PMC1538249
Thymus transplantation. Reconstitution of cellular immunity in a four-year-old patient with T-cell deficiency
Abstract
The case is reported of a 4-year-old girl affected with recurrent infections; anaemia, thrombocytopenia, haemorrhages and hepatosplenomegaly. Immunological investigations revealed a defect in cellular immunity related to the thymus-dependent system, hypergammaglobulinaemia (especially of class IgE), and very high titres of antibodies against Epstein-Barr virus (EBV). After foetal thymus transplantation, correction of the immunological defect and significant clinical improvement were noted, as well as a decrease of IgE and EBV antibody titres.
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