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. 1991 Jun 1;88(11):4728-30.
doi: 10.1073/pnas.88.11.4728.

Altered expression of insulin receptor types A and B in the skeletal muscle of non-insulin-dependent diabetes mellitus patients

L Mosthaf  1 , B Vogt, H U Häring, A Ullrich
Affiliations

Altered expression of insulin receptor types A and B in the skeletal muscle of non-insulin-dependent diabetes mellitus patients

L Mosthaf et al. Proc Natl Acad Sci U S A. .

Abstract

The human insulin receptor exists in two isoforms, HIR-A and HIR-B, which are generated by alternative splicing of a primary gene transcript and differ by a 12-amino acid insertion sequence in the alpha-subunit. The two receptor isoforms bind insulin with different affinities and are differentially expressed in human tissues. We report here a tissue-specific alteration of the insulin receptor RNA splice pattern in non-insulin-dependent diabetes mellitus (NIDDM) patients. Whereas skeletal muscle of healthy individuals contains exclusively high-affinity HIR-A-encoding RNA, we consistently find low-affinity HIR-B RNA expression in NIDDM muscle tissue at levels similar to HIR-A.

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References

    1. EMBO J. 1989 Sep;8(9):2509-17 - PubMed
    1. Biochemistry. 1979 Nov 27;18(24):5294-9 - PubMed
    1. Biochem Biophys Res Commun. 1989 Feb 28;159(1):312-6 - PubMed
    1. Diabetes. 1989 Nov;38(11):1496-500 - PubMed
    1. Diabetologia. 1987 Jun;30(6):437-40 - PubMed