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. 1991:33:417-22.
doi: 10.1007/978-3-0348-7309-3_32.

Calcium signal and histamine secretion induced by aggregation of immunoglobulin E receptors in rat basophilic leukemia (RBL-2H3) cells

K Maeyama  1 , S Yagi, M Sasaki, E Sakurai, T Watanabe
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Calcium signal and histamine secretion induced by aggregation of immunoglobulin E receptors in rat basophilic leukemia (RBL-2H3) cells

K Maeyama et al. Agents Actions Suppl. 1991.

Abstract

The changes in cytosolic Ca concentration in rat basophilic leukemia cells (RBL-2H3) were determined using a fluorescent Ca probe, fura-2, after aggregation of IgE receptors. By means of a superfusion system, both histamine secretion and changes in cytosolic Ca concentration were determined simultaneously. In addition, the microscopic observation revealed the oscillatory Ca signal after stimulation with an antigen.

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