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Review
. 2007 Apr 1;6(4):544-59.
doi: 10.1016/j.dnarep.2006.10.017. Epub 2006 Nov 16.

The mechanics of base excision repair, and its relationship to aging and disease

David M Wilson 3rd  1 , Vilhelm A Bohr
Affiliations
Review

The mechanics of base excision repair, and its relationship to aging and disease

David M Wilson 3rd et al. DNA Repair (Amst). .

Abstract

Base excision repair (BER) is the major pathway responsible for averting the mutagenic and cytotoxic effects of spontaneous hydrolytic, oxidative, and non-enzymatic alkylation DNA damage. In particular, this pathway recognizes and repairs base modifications, such as uracil and 8-hydroxyguanine, as well as abasic sites and DNA single-strand breaks. In this review, we outline the basic mechanics of the BER process, and describe the potential association of this pathway with aging and age-related disease, namely cancer and neurodegeneration.

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