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Comment
. 2006 Nov;13(11):1123-4.
doi: 10.1016/j.chembiol.2006.11.001.

A new small-molecule Stat3 inhibitor

John S McMurray  1
Affiliations
Comment

A new small-molecule Stat3 inhibitor

John S McMurray. Chem Biol. 2006 Nov.

Abstract

In this issue of Chemistry & Biology, Schust et al. report the discovery of a small molecule (Stattic) that inhibits the binding of a high affinity phosphopeptide for the SH2 domain of Stat3. Stattic is a new tool for studying Stat3 signaling and demonstrates that the SH2 domain is not a dead target.

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