Review
doi: 10.1016/j.neuron.2006.11.002.
Dissecting the coupling between the voltage sensor and pore domains
Affiliations
- PMID: 17114039
- DOI: 10.1016/j.neuron.2006.11.002
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Review
Dissecting the coupling between the voltage sensor and pore domains
Neuron.
.
Free article
Abstract
The gating mechanism of K(v) channels is not known. In this issue of Neuron, Soler-Llavina et al. present fascinating results that support the concept of relatively independent voltage-sensing modules. However, they also find that its interactions with the pore domain are rather complex, with specific S4-S5 intersubunit contacts underlying the concerted transition leading to the channel opening.
Comment on
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Functional interactions at the interface between voltage-sensing and pore domains in the Shaker K(v) channel.Neuron. 2006 Nov 22;52(4):623-34. doi: 10.1016/j.neuron.2006.10.005. Neuron. 2006. PMID: 17114047
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