doi: 10.1089/ars.2007.9.281.
Does edaravone (MCI- 186) act as an antioxidant and a neuroprotector in experimental traumatic brain injury?
Affiliations
- PMID: 17115943
- DOI: 10.1089/ars.2007.9.281
Item in Clipboard
Does edaravone (MCI- 186) act as an antioxidant and a neuroprotector in experimental traumatic brain injury?
Antioxid Redox Signal.
2007 Feb.
Abstract
Edaravone (MCI-186) is a novel synthetic free radical scavenger intended to have neuroprotective effect against ischemic insult. It is currently used on patients with cerebral infarction. Here, we note beneficial pharmaceutical effects of edaravone in rat experimental traumatic brain injury. Under specific experimental conditions, edaravone minimized traumatic brain injury by functioning as a synthetic antioxidant. Clinical trials testing the efficacy of edaravone are warranted.
Similar articles
-
Free-radical scavenger edaravone treatment confers neuroprotection against traumatic brain injury in rats.J Neurotrauma. 2011 Oct;28(10):2123-34. doi: 10.1089/neu.2011.1939. Epub 2011 Sep 27. J Neurotrauma. 2011. PMID: 21732763 Free PMC article.
-
[Pharmacological and clinical profile of the free radical scavenger edaravone as a neuroprotective agent].Nihon Yakurigaku Zasshi. 2002 May;119(5):301-8. doi: 10.1254/fpj.119.301. Nihon Yakurigaku Zasshi. 2002. PMID: 12061142 Review. Japanese.
-
Alkoxyl radical-scavenging activity of edaravone in patients with traumatic brain injury.J Neurotrauma. 2006 Nov;23(11):1591-9. doi: 10.1089/neu.2006.23.1591. J Neurotrauma. 2006. PMID: 17115906
-
The novel free radical scavenger, edaravone, increases neural stem cell number around the area of damage following rat traumatic brain injury.Neurotox Res. 2009 Nov;16(4):378-89. doi: 10.1007/s12640-009-9081-6. Epub 2009 Jul 10. Neurotox Res. 2009. PMID: 19590930
-
[Research and development of the free radical scavenger edaravone as a neuroprotectant].Yakugaku Zasshi. 2004 Mar;124(3):99-111. doi: 10.1248/yakushi.124.99. Yakugaku Zasshi. 2004. PMID: 15049127 Review. Japanese.
Cited by
-
Sedation Therapy in Intensive Care Units: Harnessing the Power of Antioxidants to Combat Oxidative Stress.Biomedicines. 2023 Jul 28;11(8):2129. doi: 10.3390/biomedicines11082129. Biomedicines. 2023. PMID: 37626626 Free PMC article.
-
Free-radical scavenger edaravone treatment confers neuroprotection against traumatic brain injury in rats.J Neurotrauma. 2011 Oct;28(10):2123-34. doi: 10.1089/neu.2011.1939. Epub 2011 Sep 27. J Neurotrauma. 2011. PMID: 21732763 Free PMC article.
-
Oxidative imbalance in HIV-1 infected patients treated with antiretroviral therapy.J Biomed Biotechnol. 2009;2009:749575. doi: 10.1155/2009/749575. Epub 2009 Oct 26. J Biomed Biotechnol. 2009. PMID: 19884983 Free PMC article.
-
Molecular hydrogen in the treatment of acute and chronic neurological conditions: mechanisms of protection and routes of administration.J Clin Biochem Nutr. 2017 Jul;61(1):1-5. doi: 10.3164/jcbn.16-87. Epub 2017 Jun 15. J Clin Biochem Nutr. 2017. PMID: 28751802 Free PMC article. Review.
-
Therapeutic time window for edaravone treatment of traumatic brain injury in mice.Biomed Res Int. 2013;2013:379206. doi: 10.1155/2013/379206. Epub 2013 Apr 10. Biomed Res Int. 2013. PMID: 23710445 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical
