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. 2007 Feb;9(2):281-7.
doi: 10.1089/ars.2007.9.281.

Does edaravone (MCI- 186) act as an antioxidant and a neuroprotector in experimental traumatic brain injury?

Kenji Dohi  1 , Kazue Satoh, Tomoya Nakamachi, Sachiko Yofu, Keisuke Hiratsuka, Shunsuke Nakamura, Hirokazu Ohtaki, Toshikazu Yoshikawa, Seiji Shioda, Tohru Aruga
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Does edaravone (MCI- 186) act as an antioxidant and a neuroprotector in experimental traumatic brain injury?

Kenji Dohi et al. Antioxid Redox Signal. 2007 Feb.

Abstract

Edaravone (MCI-186) is a novel synthetic free radical scavenger intended to have neuroprotective effect against ischemic insult. It is currently used on patients with cerebral infarction. Here, we note beneficial pharmaceutical effects of edaravone in rat experimental traumatic brain injury. Under specific experimental conditions, edaravone minimized traumatic brain injury by functioning as a synthetic antioxidant. Clinical trials testing the efficacy of edaravone are warranted.

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