Steady-state pharmacokinetics of micafungin and voriconazole after separate and concomitant dosing in healthy adults

Abstract

We assessed the pharmacokinetics and interactions of steady-state micafungin (Mycamine) or placebo with steady-state voriconazole in 35 volunteers. The 90% confidence intervals around the least-squares mean ratios for micafungin pharmacokinetic parameters and placebo-corrected voriconazole pharmacokinetic parameters were within the 80%-to-125% limits, indicating an absence of drug interaction.

FIG. 1.

Plasma concentrations (arithmetic means ± standard deviations) of voriconazole over 24 h (2 doses) on days 4 and 24 (A) and of micafungin over 24 h on days 20 and 24 (B).