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Case Reports
. 2007 Sep;166(9):981-5.
doi: 10.1007/s00431-006-0339-1. Epub 2006 Nov 21.

Adjunctive treatment of disseminated Mycobacterium avium complex infection with interferon alpha-2b in a patient with complete interferon-gamma receptor R1 deficiency

Carla M Ward  1 , Harumi Jyonouchi, Sergei V Kotenko, Sergey V Smirnov, Rakesh Patel, Helen Aguila, George McSherry, Barry Dashefsky, Steven M Holland
Affiliations
Case Reports

Adjunctive treatment of disseminated Mycobacterium avium complex infection with interferon alpha-2b in a patient with complete interferon-gamma receptor R1 deficiency

Carla M Ward et al. Eur J Pediatr. 2007 Sep.

Abstract

We report adjunct treatment of (interferon) IFN-alpha2b (Intron-A) in a patient with complete interferon-gamma receptor R1 (IFNGR1) deficiency suffering from disseminated infection with Mycobacterium avium complex (MAC) resistant to multiple anti-mycobacterial agents. A low dose of IFN-alpha2b (3 x 10(6) units/m(2) three times weekly subcutaneously) successfully attenuated progressive hepatosplenomegaly and abdominal/retroperitoneal/pelvic lymphadenopathy, although the patient continued to be mycobacteremic. This is the first report of a complete IFNGR1 deficiency treated with adjuvant IFN-alpha2b for disseminated MAC infection.

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