This site needs JavaScript to work properly. Please enable it to take advantage of the complete set of features!

Skip to main page content

Add to Collections

Your saved search

Name of saved search:

Search terms:

Test search terms

Would you like email updates of new search results?

Yes
No

Email: (change)

Frequency:

Which day?

Which day?

Report format:

Send at most:

Send even when there aren't any new results

Optional text in email:

Your RSS Feed

. 2006 Nov;174(3):1069-72.

doi: 10.1534/genetics.104.66886.

Cancer and the immortal strand hypothesis

Affiliations

PMID: 17121966
PMCID: PMC1667061
DOI: 10.1534/genetics.104.66886

Cancer and the immortal strand hypothesis

John Cairns. Genetics. 2006 Nov.

. 2006 Nov;174(3):1069-72.

doi: 10.1534/genetics.104.66886.

Author

Affiliation

¹ Clinical Trial Service Unit, University of Oxford, Oxford OX3 7LF, United Kingdom. j.cairns@ctsu.ox.ac.uk

PMID: 17121966
PMCID: PMC1667061
DOI: 10.1534/genetics.104.66886

No abstract available

PubMed Disclaimer

Similar articles

The immortal strand hypothesis: segregation and reconstruction.
Rando TA. Rando TA. Cell. 2007 Jun 29;129(7):1239-43. doi: 10.1016/j.cell.2007.06.019. Cell. 2007. PMID: 17604710 Review.
Immortal strands? Give me a break.
Lansdorp PM. Lansdorp PM. Cell. 2007 Jun 29;129(7):1244-7. doi: 10.1016/j.cell.2007.06.017. Cell. 2007. PMID: 17604711 Review.
The (not so) immortal strand hypothesis.
Tomasetti C, Bozic I. Tomasetti C, et al. Stem Cell Res. 2015 Mar;14(2):238-41. doi: 10.1016/j.scr.2015.01.005. Epub 2015 Jan 24. Stem Cell Res. 2015. PMID: 25700960 Free PMC article.
Evolutionary dynamics of adult stem cells: comparison of random and immortal-strand segregation mechanisms.
Tannenbaum E, Sherley JL, Shakhnovich EI. Tannenbaum E, et al. Phys Rev E Stat Nonlin Soft Matter Phys. 2005 Apr;71(4 Pt 1):041914. doi: 10.1103/PhysRevE.71.041914. Epub 2005 Apr 27. Phys Rev E Stat Nonlin Soft Matter Phys. 2005. PMID: 15903708
Immortal DNA strand cosegregation requires p53/IMPDH-dependent asymmetric self-renewal associated with adult stem cells.
Rambhatla L, Ram-Mohan S, Cheng JJ, Sherley JL. Rambhatla L, et al. Cancer Res. 2005 Apr 15;65(8):3155-61. doi: 10.1158/0008-5472.CAN-04-3161. Cancer Res. 2005. PMID: 15833845

See all similar articles

Cited by

Asymmetric division of stem cells and its cancer relevance.
Chao S, Yan H, Bu P. Chao S, et al. Cell Regen. 2024 Feb 27;13(1):5. doi: 10.1186/s13619-024-00188-9. Cell Regen. 2024. PMID: 38411768 Free PMC article. Review.
Microenvironmental modulation of asymmetric cell division in human lung cancer cells.
Pine SR, Ryan BM, Varticovski L, Robles AI, Harris CC. Pine SR, et al. Proc Natl Acad Sci U S A. 2010 Feb 2;107(5):2195-200. doi: 10.1073/pnas.0909390107. Epub 2010 Jan 13. Proc Natl Acad Sci U S A. 2010. PMID: 20080668 Free PMC article.
Telomeres and telomerase in normal and cancer stem cells.
Shay JW, Wright WE. Shay JW, et al. FEBS Lett. 2010 Sep 10;584(17):3819-25. doi: 10.1016/j.febslet.2010.05.026. Epub 2010 May 21. FEBS Lett. 2010. PMID: 20493857 Free PMC article. Review.
Evidence for immortality and autonomy in animal cancer models is often not provided, which causes confusion on key issues of cancer biology.
Dou X, Tong P, Huang H, Zellmer L, He Y, Jia Q, Zhang D, Peng J, Wang C, Xu N, Liao DJ. Dou X, et al. J Cancer. 2020 Mar 4;11(10):2887-2920. doi: 10.7150/jca.41324. eCollection 2020. J Cancer. 2020. PMID: 32226506 Free PMC article. Review.
Disruption of topoisomerase II perturbs pairing in drosophila cell culture.
Williams BR, Bateman JR, Novikov ND, Wu CT. Williams BR, et al. Genetics. 2007 Sep;177(1):31-46. doi: 10.1534/genetics.107.076356. Genetics. 2007. PMID: 17890361 Free PMC article.

See all "Cited by" articles

References

1. Barlow, P. W., 1976. The concept of the stem cell in the context of plant growth and development. J. Theor. Biol. 57: 433–451. - PubMed
1. Cairns, J., 1975. Mutation, selection and cancer. Nature 255: 197–200. - PubMed
1. Cairns, J., 2002. Somatic stem cells and the kinetics of mutagenesis and carcinogenesis. Proc. Natl. Acad. Sci. USA 99: 10567–10570. - PMC - PubMed
1. Cervantes, R. B., J. R. Stringer, C. Shao, J. A. Tischfield and P. J. Stambrook, 2002. Embryonic stem cells and somatic cells differ in mutation frequency and type. Proc. Natl. Acad. Sci. USA 99: 3586–3590. - PMC - PubMed
1. Cotsarelis, G., T. T. Sun and R. M. Lavker, 1990. Label-retaining cells reside in the bulge area of pilosebacious unit: implications for follicular stem cells, hair cycle, and skin carcinogenesis. Cell 61: 1329–1337. - PubMed

MeSH terms

Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions

Substances

Actions

LinkOut - more resources

Full Text Sources
Other Literature Sources
- The Lens - Patent Citations Database