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Comparative Study
. 1990 Sep;1(10):741-6.
doi: 10.1091/mbc.1.10.741.

Antiproliferative function of glia maturation factor beta

R Lim  1 , W X Zhong, A Zaheer
Affiliations
Comparative Study

Antiproliferative function of glia maturation factor beta

R Lim et al. Cell Regul. 1990 Sep.

Abstract

Recombinant human glia maturation factor beta (GMF-beta) reversibly inhibits the proliferation of neoplastic cells in culture by arresting the cells in the G0/G1 phase. This phenomenon is not target-cell specific, as neural and nonneural cells are equally inhibited. When tested simultaneously, GMF-beta suppresses the mitogenic effect of acidic fibroblasts growth factor (aFGF), but the two are synergistic in promoting the morphologic differentiation of cultured astrocytes. GMF-beta also counteracts the growth-stimulating effect of pituitary extract and cholera toxin on Schwann cells. The results underscore the regulatory role of GMF-beta and its intricate interaction with the mitogenic growth factors.

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