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. 2006 Dec;6(6):323-30.
doi: 10.1016/j.mito.2006.10.004. Epub 2006 Oct 27.

Impaired platelet mitochondrial activity in Alzheimer's disease and mild cognitive impairment

Jon Valla  1 , Lonnie Schneider, Tracy Niedzielko, Keith D Coon, Richard Caselli, Marwan N Sabbagh, Geoffrey L Ahern, Leslie Baxter, Gene Alexander, Douglas G Walker, Eric M Reiman
Affiliations

Impaired platelet mitochondrial activity in Alzheimer's disease and mild cognitive impairment

Jon Valla et al. Mitochondrion. 2006 Dec.

Abstract

Mitochondrial abnormalities are found in Alzheimer's disease (AD), but previous reports have not examined at-risk groups. In subjects with AD, mild cognitive impairment (MCI), and non-demented aged controls, platelet and lymphocyte mitochondria were isolated and analyzed for Complexes I, III, and IV of the electron transport chain. Western blots were used to control for differential enrichment of samples. Results demonstrated significant declines in Complexes III and IV in AD, and a significant decline in Complex IV in MCI. This report confirms mitochondrial deficiencies in AD, extends them to MCI, and suggests they are present at the earliest symptomatic stages of disease.

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Figures

Figure 1
Figure 1
Platelet mitochondrial Complex IV and Complex III activities in nmol cyt c / min / mg total mitochondrial isolate protein. Significant (p < 0.05) decrements in Complex IV activity were found in AD and MCI patients; significant decrements in Complex III were found in AD patients only.
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