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. 2007 Jan;28(1):1-4.
doi: 10.1016/j.it.2006.11.005. Epub 2006 Nov 28.

Zinc homeostasis and immunity

Lothar Rink  1 , Hajo Haase
Affiliations

Zinc homeostasis and immunity

Lothar Rink et al. Trends Immunol. 2007 Jan.

Abstract

Zinc is an essential trace element for the immune system, and zinc deficiency compromises the function of primarily T cells but also of several other immune cells. Recently, zinc homeostasis has been demonstrated to affect dendritic cells, in particular the involvement of zinc transport proteins during lipopolysaccharide-induced upregulation of major histocompatibility complex proteins and co-stimulatory molecules. This adds to our understanding of the immunomodulatory potential of zinc and highlights its significance for immune function.

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