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. 2007 Feb 15;17(4):1047-51.
doi: 10.1016/j.bmcl.2006.11.036. Epub 2006 Nov 16.

Novel tetrahydroisoquinolines are histamine H3 antagonists and serotonin reuptake inhibitors

Michael A Letavic  1 , John M Keith, Jill A Jablonowski, Emily M Stocking, Leslie A Gomez, Kiev S Ly, Jennifer M Miller, Ann J Barbier, Pascal Bonaventure, Jamin D Boggs, Sandy J Wilson, Kirsten L Miller, Brian Lord, Heather M McAllister, D J Tognarelli, Jiejun Wu, Marta C Abad, Carsten Schubert, Timothy W Lovenberg, Nicholas I Carruthers
Affiliations

Novel tetrahydroisoquinolines are histamine H3 antagonists and serotonin reuptake inhibitors

Michael A Letavic et al. Bioorg Med Chem Lett. .

Abstract

A series of novel 4-aryl-1,2,3,4-tetrahydroisoquinoline-based histamine H(3) ligands that also have serotonin reuptake transporter inhibitor activity is described. The synthesis, in vitro biological data, and select pharmacokinetic data for these novel compounds are discussed.

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