Triggering the brain's pathology sensor
- PMID: 17128280
- DOI: 10.1038/nn1206-1463
Triggering the brain's pathology sensor
Abstract
Microglia, the brain's intrinsic immune cells, rapidly sense brain injury and help clear cellular debris. Haynes et al. now show that P2Y12 receptors are critical for activating microglia and directing them to the site of injury.
Comment on
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The P2Y12 receptor regulates microglial activation by extracellular nucleotides.Nat Neurosci. 2006 Dec;9(12):1512-9. doi: 10.1038/nn1805. Epub 2006 Nov 19. Nat Neurosci. 2006. PMID: 17115040
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