Stimuli-responsive hydrogels based on polysaccharides incorporated with thermo-responsive polymers as novel biomaterials
- PMID: 17128423
- DOI: 10.1002/mabi.200600164
Stimuli-responsive hydrogels based on polysaccharides incorporated with thermo-responsive polymers as novel biomaterials
Abstract
In recent years, intelligent hydrogels which can change their swelling behavior and other properties in response to environmental stimuli such as temperature, pH, solvent composition and electric fields, have attracted great interest. The hydrogels based on polysaccharides incorporated with thermo-responsive polymers have shown unique properties such as biocompatibility, biodegradability, and biological functions in addition to the stimuli-responsive characters. These "smart" hydrogels exhibit single or multiple stimuli-responsive characters which could be used in biomedical applications, including controlled drug delivery, bioengineering or tissue engineering. This review focuses on the recent developments and future trends dealing with stimuli-responsive hydrogels based on grafting/blending of polysaccharides such as chitosan, alginate, cellulose, dextran and their derivatives with thermo-sensitive polymers. This review also screens the current applications of these hydrogels in the fields of drug delivery, tissue engineering and wound healing.
Similar articles
-
Biodegradable 'intelligent' materials in response to physical stimuli for biomedical applications.Expert Opin Ther Pat. 2009 Apr;19(4):493-507. doi: 10.1517/13543770902771282. Expert Opin Ther Pat. 2009. PMID: 19441928 Review.
-
In situ gelling stimuli-sensitive block copolymer hydrogels for drug delivery.J Control Release. 2008 May 8;127(3):189-207. doi: 10.1016/j.jconrel.2008.01.005. Epub 2008 Jan 26. J Control Release. 2008. PMID: 18321604 Review.
-
Biodegradable 'intelligent' materials in response to chemical stimuli for biomedical applications.Expert Opin Ther Pat. 2009 May;19(5):683-96. doi: 10.1517/13543770902769617. Expert Opin Ther Pat. 2009. PMID: 19441941 Review.
-
Stimuli-responsive polymers and their applications in drug delivery.Biomed Mater. 2009 Apr;4(2):022001. doi: 10.1088/1748-6041/4/2/022001. Epub 2009 Mar 5. Biomed Mater. 2009. PMID: 19261988 Review.
-
DNA-responsive hydrogels that can shrink or swell.Biomacromolecules. 2005 Nov-Dec;6(6):2927-9. doi: 10.1021/bm0504330. Biomacromolecules. 2005. PMID: 16283709
Cited by
-
A Biologically-Inspired Symmetric Bidirectional Switch.PLoS One. 2017 Jan 9;12(1):e0169856. doi: 10.1371/journal.pone.0169856. eCollection 2017. PLoS One. 2017. PMID: 28068391 Free PMC article.
-
pH-Responsive Chitosan/Alginate Polyelectrolyte Complexes on Electrospun PLGA Nanofibers for Controlled Drug Release.Nanomaterials (Basel). 2021 Jul 17;11(7):1850. doi: 10.3390/nano11071850. Nanomaterials (Basel). 2021. PMID: 34361236 Free PMC article.
-
Smart Hydrogels - Synthetic Stimuli-Responsive Antitumor Drug Release Systems.Int J Nanomedicine. 2020 Jun 25;15:4541-4572. doi: 10.2147/IJN.S248987. eCollection 2020. Int J Nanomedicine. 2020. PMID: 32617004 Free PMC article. Review.
-
[Fabrication of hydrophilic medical catheter with hydrogel grafting and the in vivo evaluation of its histo-compatibility].Sheng Wu Yi Xue Gong Cheng Xue Za Zhi. 2019 Apr 25;36(2):238-244. doi: 10.7507/1001-5515.201707017. Sheng Wu Yi Xue Gong Cheng Xue Za Zhi. 2019. PMID: 31016940 Free PMC article. Chinese.
-
Enzyme-free electrochemical detection of nanomolar levels of the organophosphorus pesticide paraoxon-ethyl by using a poly(N-isopropyl acrylamide)-chitosan microgel decorated with palladium nanoparticles.Mikrochim Acta. 2019 Feb 9;186(3):167. doi: 10.1007/s00604-018-3206-7. Mikrochim Acta. 2019. PMID: 30739232
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources