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Review
. 2006 Nov;73(11):973-6, 978, 981-4 passim.
doi: 10.3949/ccjm.73.11.973.

The controversy over long-acting beta agonists: examining the evidence

David M Lang  1
Affiliations
Free article
Review

The controversy over long-acting beta agonists: examining the evidence

David M Lang. Cleve Clin J Med. 2006 Nov.
Free article

Abstract

In the Salmeterol Multicenter Asthma Research Trial (SMART), patients receiving the long-acting beta agonist salmeterol--particularly African Americans--had a statistically significantly higher risk of fatal or potentially fatal asthma episodes. As a result, medications that contain salmeterol (Serevent, Advair) or formoterol (Foradil) carry a "black box warning." However, the benefits of these drugs continue to outweigh the risks, if they are used appropriately.

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