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Comparative Study
. 2007 Jan;38(1):14-8.
doi: 10.1016/j.jcv.2006.10.007. Epub 2006 Nov 28.

Human Papillomavirus testing for the management of low-grade cervical abnormalities in the UK--Influence of age and testing strategy

K S Cuschieri  1 , C Graham, C Moore, H A Cubie
Affiliations
Comparative Study

Human Papillomavirus testing for the management of low-grade cervical abnormalities in the UK--Influence of age and testing strategy

K S Cuschieri et al. J Clin Virol. 2007 Jan.

Abstract

Background: The results of the UK pilot studies were encouraging with respect to the introduction of Human Papillomavirus (HPV) testing as a means to improve the management of low-grade cytological abnormalities. However, several important unresolved issues related to HPV triage remain, two of which are: what type of HPV test should be used and what age group should be targeted.

Objectives: To perform an evaluation of two commercial HPV detection tests and to correlate disease persistence and clearance with age and HPV status by the two tests.

Study design: We performed an evaluation of two commercial HPV tests in a cross-sectional analysis of 322 cervical cytology specimens with low-grade abnormalities. A subset of these specimens were then examined longitudinally, in order to correlate disease persistence and clearance with age and HPV status by the two detection tests.

Results: The two tests performed similarly with respect to the longitudinal identification/prediction of high-grade cervical disease. Age did not appear to be a factor in determining which cases went on to manifest high-grade disease within 3 years of a low-grade result (p=0.678).

Conclusions: This study weakens the case for age-adjusted HPV triage of low-grade cervical abnormalities.

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