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Comment
. 2006 Dec 1;127(5):877-9.
doi: 10.1016/j.cell.2006.11.018.

ER targeting signals: more than meets the eye?

Eileithyia Swanton  1 , Stephen High
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ER targeting signals: more than meets the eye?

Eileithyia Swanton et al. Cell. .
Free article

Abstract

The signal sequences that target newly synthesized proteins to the endoplasmic reticulum are highly variable; however, the functional significance of this diversity has remained obscure. In this issue, Kang et al. (2006) report that variability in signal sequences allows the cell to selectively regulate the translocation of proteins into the endoplasmic reticulum in a substrate-specific manner.

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