Comment
doi: 10.1016/j.cell.2006.11.020.
A role for p130Cas in mechanotransduction
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- PMID: 17129774
- DOI: 10.1016/j.cell.2006.11.020
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Comment
A role for p130Cas in mechanotransduction
Cell.
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Free article
Abstract
Focal adhesions are sites of contact between cells and the extracellular matrix. Sawada et al. (2006) now report that the mechanical stretching of cells forces p130Cas, an adaptor protein at focal adhesions, to undergo a conformational change. This change promotes phosphorylation of p130Cas by Src family kinases and the transduction of integrin-mediated signaling.
Comment on
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Force sensing by mechanical extension of the Src family kinase substrate p130Cas.Cell. 2006 Dec 1;127(5):1015-26. doi: 10.1016/j.cell.2006.09.044. Cell. 2006. PMID: 17129785 Free PMC article.
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